Inhibiting Translation One Protein at a Time

Publication date: Available online 15 May 2017
Source:Trends in Biochemical Sciences
Author(s): Matthew D. Disney
Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome's nascent chain [1], opening up a new therapeutic strategy for 'undruggable' proteins.



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