On the Formation of Digits and Joints during Limb Development

Publication date: 5 June 2017
Source:Developmental Cell, Volume 41, Issue 5
Author(s): Tom W. Hiscock, Patrick Tschopp, Clifford J. Tabin
Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.

Teaser

The positioning of digits, and of joints within each digit, are critical steps in vertebrate limb formation. Recent studies have proposed that a Turing-like mechanism establishes iterative series of digits. Hiscock et al. reconsider the basis of these conclusions and suggest that an integrated model is required to understand digit and joint patterning.


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