Lipid Droplets Guard Mitochondria during Autophagy

Publication date: 10 July 2017
Source:Developmental Cell, Volume 42, Issue 1
Author(s): Till Klecker, Ralf J. Braun, Benedikt Westermann
In this issue of Developmental Cell, Nguyen et al. (2017) show that lipid droplets serve a dual purpose during starvation. First, they act as an energy source by supplying fatty acids for mitochondrial β oxidation. Second, they sequester toxic lipids that arise during autophagic degradation of membranous organelles, thereby protecting mitochondria.

Teaser

In this issue of Developmental Cell, Nguyen et al. (2017) show that lipid droplets serve a dual purpose during starvation. First, they act as an energy source by supplying fatty acids for mitochondrial β oxidation. Second, they sequester toxic lipids that arise during autophagic degradation of membranous organelles, thereby protecting mitochondria.


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