Phase-locked and non-phase-locked EEG responses to pinprick stimulation before and after experimentally-induced secondary hyperalgesia

Publication date: August 2017
Source:Clinical Neurophysiology, Volume 128, Issue 8
Author(s): Emanuel N. van den Broeke, Bart de Vries, Julien Lambert, Diana M. Torta, André Mouraux
ObjectivePinprick-evoked brain potentials (PEPs) have been proposed as a technique to investigate secondary hyperalgesia and central sensitization in humans. However, the signal-to-noise (SNR) of PEPs is low. Here, using time-frequency analysis, we characterize the phase-locked and non-phase-locked EEG responses to pinprick stimulation, before and after secondary hyperalgesia.MethodsSecondary hyperalgesia was induced using high-frequency electrical stimulation (HFS) of the left/right forearm skin in 16 volunteers. EEG responses to 64 and 96mN pinprick stimuli were elicited from both arms, before and 20min after HFS.ResultsPinprick stimulation applied to normal skin elicited a phase-locked low-frequency (<5Hz) response followed by a reduction of alpha-band oscillations (7–10Hz). The low-frequency response was significantly increased when pinprick stimuli were delivered to the area of secondary hyperalgesia. There was no change in the reduction of alpha-band oscillations. Whereas the low-frequency response was enhanced for both 64 and 96mN intensities, PEPs analyzed in the time domain were only significantly enhanced for the 64mN intensity.ConclusionsTime-frequency analysis may be more sensitive than conventional time-domain analysis in revealing EEG changes associated to secondary hyperalgesia.SignificanceTime-frequency analysis of PEPs can be used to investigate central sensitization in humans.



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