Optimal Contractile Forces for a Mesenchymal Engine

Publication date: 21 August 2017
Source:Developmental Cell, Volume 42, Issue 4
Author(s): Dennis E. Discher, Lawrence J. Dooling
The cell and molecular mechanisms that cause a smooth epithelium to become topographically patterned during development are poorly understood. In a recent issue of Science, Shyer et al. (2017) show that myosin II contractility drives the smooth dermal mesenchyme into a pattern of surface bumps that triggers epithelial gene expression.

Teaser

The cell and molecular mechanisms that cause a smooth epithelium to become topographically patterned during development are poorly understood. In a recent issue of Science, Shyer et al. (2017) show that myosin II contractility drives the smooth dermal mesenchyme into a pattern of surface bumps that triggers epithelial gene expression.


http://ift.tt/2vTKQU4