Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage

Publication date: 1 August 2017
Source:Cell Reports, Volume 20, Issue 5
Author(s): Hong Wang, Elyse van Spyk, Qiang Liu, Mikhail Geyfman, Michael L. Salmans, Vivek Kumar, Alexander Ihler, Ning Li, Joseph S. Takahashi, Bogi Andersen
The epidermis is a highly regenerative barrier protecting organisms from environmental insults, including UV radiation, the main cause of skin cancer and skin aging. Here, we show that time-restricted feeding (RF) shifts the phase and alters the amplitude of the skin circadian clock and affects the expression of approximately 10% of the skin transcriptome. Furthermore, a large number of skin-expressed genes are acutely regulated by food intake. Although the circadian clock is required for daily rhythms in DNA synthesis in epidermal progenitor cells, RF-induced shifts in clock phase do not alter the phase of DNA synthesis. However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between circadian rhythm, food intake, and skin health.

Graphical abstract

Teaser

Little is known about the effect of time of feeding on skin function. Wang et al. find that time-restricted feeding schedules affect skin gene expression, epidermal progenitor cell proliferation, and UVB-induced DNA damage, pointing to a modulatory role for food-intake timing in skin biology.


http://ift.tt/2hmxLgT