A statistical view of protein chemical synthesis using NCL and extended methodologies

Publication date: 15 September 2017
Source:Bioorganic & Medicinal Chemistry, Volume 25, Issue 18
Author(s): Vangelis Agouridas, Ouafâa El Mahdi, Marine Cargoët, Oleg Melnyk
Native chemical ligation and extended methodologies are the most popular chemoselective reactions for protein chemical synthesis. Their combination with desulfurization techniques can give access to small or challenging proteins that are exploited in a large variety of research areas. In this report, we have conducted a statistical review of their use for protein chemical synthesis in order to provide a flavor of the recent trends and identify the most popular chemical tools used by protein chemists. To this end, a protein chemical synthesis (PCS) database (http://pcs-db.fr) was created by collecting a set of relevant data from more than 450 publications covering the period 1994–2017. A preliminary account of what this database tells us is presented in this report.

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