Development of a solid dosage platform for the oral delivery of bilayer vesicles

Publication date: 15 October 2017
Source:European Journal of Pharmaceutical Sciences, Volume 108
Author(s): Jitinder S. Wilkhu, Sarah E. McNeil, David E. Anderson, Marc Kirchmeier, Yvonne Perrie
Within this work, we develop vesicles incorporating sub-unit antigens as solid dosage forms suitable for the oral delivery of vaccines. Using a combination of trehalose, dextran and mannitol, freeze-dried oral disintegrating tablets were formed which upon rehydration release bilayer vesicles incorporating antigen. Initial studies focused on the optimisation of the freeze-dry cycle and subsequently excipient content was optimised by testing tablet hardness, disintegration time and moisture content. The use of 10% mannitol and 10% dextran produced durable tablets which offered strong resistance to mechanical damage yet appropriate disintegration times and dispersed to release niosomes-entrapping antigen. From these studies, we have formulated a bilayer vesicle vaccine delivery system as rapid disintegrating tablets and capsules.

Graphical abstract

http://ift.tt/2w4NZlT