Immunosurveillance of Malignant Cells with Complex Karyotypes

Publication date: Available online 19 September 2017
Source:Trends in Cell Biology
Author(s): Alejandro López-Soto, Segundo Gonzalez, Carlos López-Larrea, Guido Kroemer
A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.



http://ift.tt/2xnazVF