Tailoring Diagnostic Studies in Hand, Foot, and Mouth Disease: Utility of PCR testing of Lesional Skin

Hand, Foot, Mouth Disease (HFMD) is a highly contagious enteroviral infection with the potential for significant morbidity. In recent years, there has been an increase in atypical cutaneous manifestations of HFMD. We present a pilot case series utilizing Polymerase Chain Reaction (PCR) testing of lesional skin to render a diagnosis of HFMD. These preliminary results suggest that lesional skin PCR testing could be an effective and minimally-invasive test for diagnosing HFMD.

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