An inverse association between serum resistin levels and n-3 polyunsaturated fatty acids intake was strongest in the SNP-420 G/G genotype in the Japanese cohort: The Toon Genome Study

Abstract

Objective

Resistin is secreted from monocytes/macrophages and is associated with insulin resistance, inflammation, and cardiovascular diseases. In the Japanese cohort, serum resistin is tightly associated with a single nucleotide polymorphism (SNP) at -420 (rs1862513) in the promoter region of the human resistin gene. However, interactions between SNP-420 and environmental factors remain to be elucidated. The aim of this study was to investigate the association between serum resistin levels and nutrient intake, and the effect of SNP-420 on this association.

Design, Participants, and Measurements

The Toon Genome Study is a cohort study of Japanese community-dwelling subjects. A total of 1981 participants were cross-sectionally analyzed. Each nutrient intake was assessed using the semiquantitative food frequency questionnaire, and categorized into the quartiles (Q1-Q4). Serum resistin was measured by ELISA.

Results

Serum resistin tended to be inversely associated with fish intake and positively associated with meat intake after adjustment for age, sex, BMI, and energy intake. Serum resistin was inversely associated with n-3 polyunsaturated fatty acids (PUFA) intake after adjustment for age, sex, BMI, and energy intake (Q1 12.5, Q2 12.5, Q3 12.2, Q4 11.5 ng/ml; P for trend=0.007). This inverse association was strongest in the G/G genotype of SNP-420, followed by C/G and C/C (G/G, Q1 18.9, Q2 19.5, Q3 18.4, Q4 14.5 ng/ml, P=0.001; C/G, 14.4, 13.3, 13.1, 12.9, P=0.015; C/C, 9.5, 9.5, 9.2, 8.8, P=0.020; P for interaction=0.004).

Conclusions

The inverse association between serum resistin and n-3 PUFA intake was strongest in SNP-420 G/G genotype in the Japanese cohort.

This article is protected by copyright. All rights reserved.

http://ift.tt/2yrwjyx