Ineffective Erythropoiesis: Anemia and Iron Overload

Publication date: Available online 29 December 2017
Source:Hematology/Oncology Clinics of North America
Author(s): Ritama Gupta, Khaled M. Musallam, Ali T. Taher, Stefano Rivella

Teaser

Stress erythropoiesis (SE) is characterized by an imbalance in erythroid proliferation and differentiation under increased demands of erythrocyte generation and tissue oxygenation. β-thalassemia represents a chronic state of SE, called ineffective erythropoiesis (IE), exhibiting an expansion of erythroid-progenitor pool and deposition of alpha chains on erythrocyte membranes, causing cell death and anemia. Concurrently, there is a decrease in hepcidin expression and a subsequent state of iron overload. There are substantial investigative efforts to target increased iron absorption under IE. There are also avenues for targeting cell contact and signaling within erythroblastic islands under SE, for therapeutic benefits.


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