Melanoma of the Face and Mohs Micrographic Surgery: Nationwide Mortality Data Analysis

BACKGROUND Although Mohs micrographic surgery (MMS), narrow margin excision (NME), and wide margin excision (WME) are commonly used to treat melanoma of the face, there is a paucity of data comparing mortality outcomes for each method. OBJECTIVE To determine the association between surgical method used to treat cutaneous melanoma of the face and patient survival. MATERIALS AND METHODS A retrospective review of Surveillance, Epidemiology, and End Results registries for patients diagnosed with melanoma of the face between 2003 and 2012 was conducted. RESULTS The authors query resulted in 43,443 records. Patients with melanoma were more likely to undergo NME (57.79%) than WME (27.86%) or MMS (14.36%). Overall 5-year risk of death was higher with WME (hazard ratio [HR], 1.11; 95% confidence interval [CI], 1.00–1.23; p = .043) and NME (HR, 1.10; 95% CI, 1.00–1.20; p = .046) relative to MMS after adjusting for patient demographics, residence socioeconomic factors, and tumor characteristics. No statistically significant difference in melanoma-specific mortality was found between different surgical methods on multivariate analysis. CONCLUSION Patients with melanoma of the face treated with MMS had similar melanoma-specific mortality or overall survival outcome as patients treated by other surgical modalities. Address correspondence and reprint requests to: Nathalie C. Zeitouni, MDMC, FRCPC, University of Arizona, College of Medicine—Phoenix, University of Arizona Cancer Center at Dignity Health, 625 N. 6th Street, Phoenix, AZ 85004, or e-mail: nathaliezeitouni@email.arizona.edu Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the full text and PDF versions of this article on the journal's Web site (http://ift.tt/2bw6lgr). The authors have indicated no significant interest with commercial supporters. © 2017 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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