New sensor based on membranes with magnetic nano-inclusions for early diagnosis in periodontal disease

Publication date: 15 April 2018
Source:Biosensors and Bioelectronics, Volume 102
Author(s): Eugenia Eftimie Totu, Ibrahim Isildak, Aurelia Cristina Nechifor, Corina Marilena Cristache, Marius Enachescu
A series of sodium selective membranes with magnetic nano-inclusions using p-tertbutyl calix[4]arene as ionophore and polymeric matrix (polyvinyl chloride) have been developed, and the corresponding sodium selective sensors were obtained for the first time. A linear range was registered between 3.1 × 10⁻⁵ and 10⁻¹moldm⁻³ and near Nernstian electrochemical answer: 55.73mV/decade has been recoreded for PVC (polyvinyl chloride) – based sodium selective sensor, with a response time of 45s. Due to their small dimensions, sensors could be used for measuring ions from the gingival crevicular fluid directly into the peri-odontal pocket, avoiding the difficulties of collecting an appropriate amount of fluid for analysis. Alterations in the inorganic ions level could be evidenced with this new device, assisting the early diagnosis and prevention of periodontal disease.

Graphical abstract

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