Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Publication date: 5 December 2017
Source:Cell Metabolism, Volume 26, Issue 6
Author(s): Avital Swisa, Klaus H. Kaestner, Yuval Dor
The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

Teaser

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.


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