When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade

Publication date: 5 December 2017
Source:Cell Metabolism, Volume 26, Issue 6
Author(s): Mengrou Shan, Costas A. Lyssiotis
In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.

Teaser

In normal physiology, end-products of metabolism are excreted from the body. In tumors, these metabolic wastes accumulate due to deregulated metabolism and vascular insufficiency. Spinelli et al. (2017) show that breast cancer cells adapt to ammonia buildup by recycling it for amino acid synthesis, which can support cancer cell growth.


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