When Clarity Is Crucial: Regulating Ocular Surface Immunity

Publication date: Available online 14 December 2017
Source:Trends in Immunology
Author(s): William Foulsham, Giulia Coco, Afsaneh Amouzegar, Sunil K. Chauhan, Reza Dana
The ocular surface is a unique mucosal immune compartment in which anatomical, physiological, and immunological features act in concert to foster a particularly tolerant microenvironment. These mechanisms are vital to the functional competence of the eye, a fact underscored by the devastating toll of excessive inflammation at the cornea – blindness. Recent data have elucidated the contributions of specific anatomical components, immune cells, and soluble immunoregulatory factors in promoting homeostasis at the ocular surface. We highlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current knowledge.



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