Development of a multivariate model of the six-minute walked distance to predict functional exercise capacity in hypertension

Publication date: Available online 31 January 2018
Source:Journal of Bodywork and Movement Therapies
Author(s): Rodrigo de Assis Ramos, Fernando Silva Guimarães, Yannis Dionyssiotis, Dorothea Tsekoura, Jannis Papathanasiou, Arthur de Sá Ferreira
BackgroundHypertension is associated with deterioration of musculoskeletal function and functional capacity. Existing prediction models for assessment of the 6-min walk test (6MWT) do not capture the disease-related functional capacity. This study developed a multivariate prediction model of the measured 6-min walked distance (6MWDM) in hypertension and proposed target-values based on optimal therapeutic aims.MethodsSeventy-six patients (38 men, 56.1 ± 14.3 years, systolic pressure 156.7 ± 17.5 mmHg, diastolic pressure 92.9 ± 6.9 mmHg) underwent anamnesis, physical examination, and laboratory analysis. Functional capacity was assessed using the 6MWT, being the 6MWDM considered as the dependent variable. Independent variables included sex (S, coded 'male' = 1, 'female' = 0), age (A), body height (H), body mass, mean blood pressure (MBP), and physical activity (IPAQ, coded 1–5). Target-values were derived from theoretical scenarios of optimal blood pressure and physical activity, separately and combined.ResultsPatients walked 324.5 ± 10.1 m in the average of two trials 30-min apart. Pearson's correlation coefficient showed moderate-to-weak significant associations between 6MWDM and all independent variables. The final multivariate model was 6MWDP = 611.347–4.446 × MBP + 267.630 × H – 1.511 × A + IPAQcode + Scode (adjusted R² = 0.680, SE of bias = 6.3 m), suggesting that clinical, anthropometric, and hemodynamic information determines functional capacity. Predicted values yielded a group-average of 325 ± 87 m. Target-values under the optimal scenario resulted in 420 ± 60 m.ConclusionsSex (men), higher body height, higher physical activity, lower mean blood pressure, and lower age are independently correlated with higher 6MWDM in patients with hypertension. Target-values can be estimated for therapeutic aims related to hemodynamics and lifestyle.



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