HIV Immunogens: Affinity Is Key

Publication date: 16 January 2018
Source:Immunity, Volume 48, Issue 1
Author(s): Savit Prabhu, Ian A. Cockburn, Carola G. Vinuesa
Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

Teaser

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.


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