NKTeeing Up B Cell Responses to Viral Infection

Publication date: 20 February 2018
Source:Immunity, Volume 48, Issue 2
Author(s): Mary F. Fontana, Marion Pepper
Activated B cells mature in germinal centers (GCs), but GC initiation during infection is poorly understood. Gaya et al. (2018) show that NKT cells, activated by CD169⁺ macrophages, produce an early wave of interleukin-4 (IL-4) that promotes GC formation during viral infection.

Teaser

Activated B cells mature in germinal centers (GCs), but GC initiation during infection is poorly understood. Gaya et al. (2018) show that NKT cells, activated by CD169⁺ macrophages, produce an early wave of interleukin-4 (IL-4) that promotes GC formation during viral infection.


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