Pulmonary Colonization Resistance to Pathogens via Non-Canonical Wnt and IL-17A by Intranasal pep27 Mutant Immunization.

Pulmonary Colonization Resistance to Pathogens via Non-Canonical Wnt and IL-17A by Intranasal pep27 Mutant Immunization.

J Infect Dis. 2018 Mar 22;:

Authors: Kim GL, Lee S, Kim SJ, Lee SO, Pyo S, Rhee DK

Abstract
Colonization resistance has been focused on the gut microbiota against antibiotic resistant strains. However, less research has been performed on respiratory colonization resistance. Since respiratory colonization is the first step of respiratory infections, intervention to prevent colonization would represent a new approach for preventive and therapeutic measures. The Th17 response plays an important role in clearance of respiratory pathogens. Thus, harnessing the Th17 immune response in the mucosal site would be an effective method to design a respiratory mucosal vaccine. Here, we showed that intranasal Δpep27 immunization induces non-canonical Wnt and subsequent interleukin (IL)-17 secretion, and inhibits Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae colonization. Moreover, IL-17A neutralization or nuclear factor of activated T-cells (NFAT) inhibition augmented bacterial colonization, indicating that non-canonical Wnt signaling is involved in pulmonary colonization resistance. Therefore, Δpep27 immunization can provide non-specific respiratory colonization resistance via non-canonical Wnt signaling and IL-17A-related pathways.

PMID: 29579238 [PubMed - as supplied by publisher]

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