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Πέμπτη 1 Μαρτίου 2018

Scholar : Xenobiotica, Volume 48, Issue 5, May 2018 is now available online on Taylor & Francis Online

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Xenobiotica, Volume 48, Issue 5, May 2018 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

General Xenobiochemistry

Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid
Svenja Heischmann & Uwe Christians
Pages: 433-441 | DOI: 10.1080/00498254.2017.1329567


Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition
Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas
Pages: 442-451 | DOI: 10.1080/00498254.2017.1329568


Everolimus-inhibited multiple isoforms of UDP-glucuronosyltransferases (UGTs)
Zuo Du, Guang Wang, Yun-Feng Cao, Cui-Min Hu, Kun Yang, Yong-Zhe Liu, Chun-Ze Zhang, Wei-Hua Zhang, Zhi-Tu Zhu, Hong-Zhi Sun, Xiao-Yu Sun, Mo Hong & Zhong-Ze Fang
Pages: 452-458 | DOI: 10.1080/00498254.2017.1335917


Clinical Pharmacokinetics and Metabolism

Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6
Xia Chen, Ji Jiang, Nagdeep Giri & Pei Hu
Pages: 459-466 | DOI: 10.1080/00498254.2017.1342881


Animal Pharmacokinetics and Metabolism

Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP)
Mingxiang Liao, Bei-Ching Chuang, Qing Zhu, Yuexian Li, Emily Guan, Shaoxia Yu, Johnny Yang, Shimoga Prakash & Cindy Q. Xia
Pages: 467-477 | DOI: 10.1080/00498254.2017.1328147


New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso & Giorgio Grosa
Pages: 478-487 | DOI: 10.1080/00498254.2017.1342288


Molecular Toxicology

Reaction products of hexamethylene diisocyanate vapors with "self" molecules in the airways of rabbits exposed via tracheostomy
Adam V. Wisnewski, Jean Kanyo, Jennifer Asher, James A. Goodrich, Grace Barnett, Lyn Patrylak, Jian Liu, Carrie A. Redlich & Ala F. Nassar
Pages: 488-497 | DOI: 10.1080/00498254.2017.1329569


The effect of ethanol and N-nitrosodimethylamine on the iNOS-dependent NO production in human neutrophils. Role of NF-κB
Karolina Nowak, Wioletta Ratajczak-Wrona, Marzena Garley & Ewa Jabłońska
Pages: 498-505 | DOI: 10.1080/00498254.2017.1342150


Topics in Xenobiochemistry

Efflux proteins at the blood–brain barrier: review and bioinformatics analysis
Massoud Saidijam, Fatemeh Karimi Dermani, Sareh Sohrabi & Simon G. Patching
Pages: 506-532 | DOI: 10.1080/00498254.2017.1328148


Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans
Jinfang Jiang, Xiaoyan Chen & Dafang Zhong
Pages: 533-540 | DOI: 10.1080/00498254.2017.1333658


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