Terpenoids isolated from Chinese liverworts Lepidozia reptans and their anti-inflammatory activity

Publication date: Available online 27 March 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Siwen Li, Huanmin Niu, Yanan Qiao, Rongxiu Zhu, Yong Sun, Zhaojie Ren, Huiqing Yuan, Yun Gao, Yi Li, Wang Chen, Jinchuan Zhou, Hongxiang Lou
Five new terpenoids (1–5) including two dollabellane-type, one ent-kaurane-type diterpenoids and two sesquiterpenoids were isolated from the Chinese liverwort Lepidozia reptans (L.) Dumort., together with nine known terpenoids (6–14). Their structures were determined on the basis of analysis of MS and NMR spectroscopic data, single-crystal X–ray diffraction and electronic circular dichroism calculations. The selected compounds 1, 2, 6, 7, 9 and 14 were screened for anti-inflammatory activities by the model of LPS-induced nitric oxide (NO) production with macrophage cells, and the mechanism of the active compounds 1 and 2 were further explored.

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