Source:Medical Hypotheses
Author(s): Susana Cifre, Mónica Gozalbo, Vicente Ortiz, José M. Soriano, J. Francisco Merino, María Trelis
Blastocystis spp. is a common intestinal protozoan that affects humans and animals. The role of this parasite as a pathogen is still controversial and it is suspected to be linked to Irritable Bowel Syndrome (IBS), a functional bowel disorder characterized by chronic or recurrent abdominal pain associated with altered intestinal habits. A broad search in electronic databases, libraries, portals of journals, etc. for reports on the association between the parasite and IBS without language restriction was performed. The selection was not restricted by date, but articles published in the last seven years were given preference. We investigated the evidence regarding Blastocystis and IBS coexistence as well as the implications of the parasite in pathogenesis and clinical manifestations. Only standardized parasitological tools, supplemented by epidemiological analysis, will be able to clarify whether parasite carriage could be connected to IBS and its status as a human pathogen. Although a variation in pathogenicity and virulence between subtypes has been confirmed, Blastocystis can only be considered an indicator of dysbiosis. Accurate diagnoses of this parasitic eukaryote, specifically at genotypic and phenotypic levels, as well as the complete analysis of the intestinal microbial communities, have to be included in the protocol of those patients with IBS.
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