Drug delivery systems and materials for wound healing applications

Publication date: Available online 5 April 2018
Source:Advanced Drug Delivery Reviews
Author(s): Saghi Saghazadeh, Chiara Rinoldi, Maik Schot, Sara Saheb Kashaf, Fatemeh Sharifi, Elmira Jalilian, Kristo Nuutila, Giorgio Giatsidis, Pooria Mostafalu, Hossein Derakhshandeh, Kan Yue, Wojciech Swieszkowski, Adnan Memic, Ali Tamayol, Ali Khademhosseini
Chronic, non-healing wounds place a significant burden on patients and healthcare systems, resulting in impaired mobility, limb amputation, or even death. Chronic wounds result from a disruption in the highly orchestrated cascade of events involved in wound closure. Significant advances in our understanding of the pathophysiology of chronic wounds have resulted in the development of drugs designed to target different aspects of the impaired processes. However, the hostility of the wound environment rich in degradative enzymes and its elevated pH, combined with differences in the time scales of different physiological processes involved in tissue regeneration require the use of effective drug delivery systems. In this review, we will first discuss the pathophysiology of chronic wounds and then the materials used for engineering drug delivery systems. Different passive and active drug delivery systems used in wound care will be reviewed. In addition, the architecture of the delivery platform and its ability to modulate drug delivery are discussed. Emerging technologies and the opportunities for engineering more effective wound care devices are also highlighted.

Graphical abstract

https://ift.tt/2IyGkhq