A Novel Regulator of Type II Diabetes: MicroRNA-143

Publication date: June 2018
Source:Trends in Endocrinology & Metabolism, Volume 29, Issue 6
Author(s): Biao Li, Jingjing Fan, Ning Chen
MiR-143 is an miRNA with the function of specifically inhibiting the insulin-AKT pathway via the downregulation of oxysterol-binding protein-related protein 8 (ORP8), thus resulting in the inhibition of AKT phosphorylation, insulin tolerance, and final development of type II diabetes mellitus (T2DM). Aerobic exercise can prevent T2DM by downregulating miR-143. However, the underlying mechanisms for exercise-induced change of miR-143 remain unclear. In the present study, we will summarize the involvement of miR-143 in regulating the development of T2DM and the underlying mechanisms for potential diagnosis, prevention, and treatments, including exercise intervention for T2DM by targeting miR-143.



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