Adipose Stromal Vascular Fraction Gel Grafting: A New Method for Tissue Volumization and Rejuvenation

BACKGROUND The clinical outcomes of fat grafting vary and are technique-dependent. Stromal vascular fraction (SVF) gel is a novel, mechanically processed fat product with high concentrations of adipose tissue–derived stem cells and other SVF cells. This study evaluated the volumization and rejuvenation effects of SVF-gel. OBJECTIVE This study evaluated the volumization and rejuvenation effects of SVF-gel. METHODS This retrospective, single-center study included 126 patients who underwent SVF-gel grafting and 78 who underwent conventional lipoinjection for various indications from March 2015 to February 2017. Patient satisfaction and secondary surgery rates were evaluated. Samples of transferred SVF-gel were harvested and examined histologically. RESULTS All patients showed improvements in facial augmentation and contour. Patients in the SVF-gel group experienced mild postoperative swelling and a low secondary surgery rate (10.9%). Assessment of patient-rated satisfaction on a 5-point Likert scale found that 77.3% of patients in the SVF-gel group were satisfied (54.5%) or very satisfied (22.8%) with their outcomes. By comparison, 53.8% of patients who underwent conventional lipoinjection were satisfied (48.7%) or very satisfied (5.1%). Moreover, SVF-gel showed effective antiwrinkle and skin rejuvenation effects. Hematoxylin–eosin staining showed a normal adipose tissue structure in transferred SVF-gel. CONCLUSION Stromal vascular fraction gel is effective for both volumization and rejuvenation, and may be superior to conventional lipoinjection for facial recontouring. Address correspondence and reprint requests to: Feng Lu, MD, PhD, Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guang Zhou, Guang Dong, 510515, People's Republic of China, or e-mail: doctorlufeng@hotmail.com Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the full text and PDF versions of this article on the journal's Web site (https://ift.tt/2bw6lgr). Supported by National Nature Science Foundation of China (81471881, 81772101, 81601702, 81671931, 81701920), Natural Science Foundation of Guangdong Province of China (2017A030313900), and President Foundation of Nanfang Hospital (2014B009, 2015Z002, 2016Z010, 2016C032). The authors have indicated no significant interest with commercial supporters. Y. Yao and J. Cai contributed equally to this study and should be considered co-first authors. F. Lu and Z. Dong should be considered co-corresponding authors. © 2018 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.

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