Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation

Publication date: Available online 22 June 2018
Source:Trends in Biochemical Sciences
Author(s): Yongsheng Li, Daniel J. McGrail, Juan Xu, Gordon B. Mills, Nidhi Sahni, Song Yi
Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.



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