Innate Lymphoid Cell Development: A T Cell Perspective

Publication date: 19 June 2018
Source:Immunity, Volume 48, Issue 6
Author(s): Dylan E. Cherrier, Nicolas Serafini, James P. Di Santo
Innate lymphoid cells (ILCs) and natural killer (NK) cells have garnered considerable interest due to their unique functional properties in immune defense and tissue homeostasis. Our current understanding of how these cells develop has been greatly facilitated by knowledge of T cell biology. Models of T cell differentiation provided the basis for a conceptual classification of these innate effectors and inspired a scheme of their activation and regulation. In this review, we discuss NK cell and ILC development from a "T cell standpoint" in an attempt to extend the analogy between adaptive T cells and their innate ILC and NK cell counterparts.

Teaser

An extended family of innate lymphoid cells (ILCs) and natural killer (NK) are proposed to represent "innate" versions of adaptive helper and cytotoxic T cells, respectively. Here, Di Santo and colleagues examine the developmental lifestyles of ILCs and NK cells through the lens of the well-known T cell differentiation pathways.


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