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Τρίτη 5 Ιουνίου 2018

Scholar : Xenobiotica, Volume 48, Issue 8, August 2018 is now available online on Taylor & Francis Online

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Xenobiotica, Volume 48, Issue 8, August 2018 is now available online on Taylor & Francis Online.



This new issue contains the following articles:

General Xenobiochemistry

Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes
Kazuyuki Nakanishi, Shotaro Uehara, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 757-763 | DOI: 10.1080/00498254.2017.1363444


In vitro inhibition of human UGT isoforms by ritonavir and cobicistat
Sara Algeelani, Novera Alam, Md Amin Hossain, Gerd Mikus & David J. Greenblatt
Pages: 764-769 | DOI: 10.1080/00498254.2017.1370655


Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes
Shinji Iwasaki, Hideki Hirabayashi & Nobuyuki Amano
Pages: 770-780 | DOI: 10.1080/00498254.2017.1370744


Indirect regulation of CYP2C19 gene expression via DNA methylation
Kathryn Elisa Burns, Phillip Shepherd, Graeme Finlay, Malcolm Drummond Tingle & Nuala Ann Helsby
Pages: 781-792 | DOI: 10.1080/00498254.2017.1372648


Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat
Yildiz Yilmaz, Kenichi Umehara, Gareth Williams, Thomas Faller, Hilmar Schiller, Markus Walles, Stephan Kraehenbuehl, Gian Camenisch & Nenad Manevski
Pages: 793-803 | DOI: 10.1080/00498254.2017.1373311


Clinical Pharmacokinetics and Metabolism

Pharmacokinetic study of methylnaltrexone after single and multiple subcutaneous administrations in healthy Chinese subjects
Dan Zhang, Jing-Yi Ma, Man Yang, Ming Deng & Huichen Liu
Pages: 804-808 | DOI: 10.1080/00498254.2017.1364449


Population pharmacokinetics of arginine glutamate in healthy Chinese volunteers
Jing Wang, Heng Zheng, Kun Wang, Zheng Wang & Yufeng Ding
Pages: 809-817 | DOI: 10.1080/00498254.2017.1370745


Animal Pharmacokinetics and Metabolism

Effects of safflower injection on the pharmacodynamics and pharmacokinetics of warfarin in rats
Yan Liu, Shuang Liu, Yuan Shi, Mengnan Qin, Zhidan Sun & Gaofeng Liu
Pages: 818-823 | DOI: 10.1080/00498254.2017.1361051


Comparative pharmacokinetics of (S)-MP3950, a novel 5-HT4 receptor agonist, in normal and atropine-induced gastrointestinal motility disorders rats
Binjie Wang, Xiaoyang Sun, Shixiao Wang, Ping Guo, Shujuan Li, Meiyu Zhang, Longshan Zhao & Xiaohui Chen
Pages: 824-830 | DOI: 10.1080/00498254.2017.1365974


Pharmacokinetics of tafamidis, a transthyretin amyloidosis drug, in rats
Kyeong-Ryoon Lee, Jong-Woo Jeong, Hun-Chan Hyun, Eunseo Jang, Sunjoo Ahn, Sungwook Choi, Sang Hoon Joo, Sungsub Kim & Tae-Sung Koo
Pages: 831-838 | DOI: 10.1080/00498254.2017.1366575


Effects of verapamil on the pharmacokinetics of dihydromyricetin in rats and its potential mechanism
Yixiang Huang, Junyong Zhao, Wei Jian & Gang Wang
Pages: 839-844 | DOI: 10.1080/00498254.2017.1366576


Pharmacokinetic evaluation of β-caryophyllene alcohol in rats and beagle dogs
Jiake He, Sufeng Zhou, Xiaonan Li, Chunfeng Wang, Yang Yu, Xijing Chen & Yang Lu
Pages: 845-850 | DOI: 10.1080/00498254.2017.1367441


Evaluation of brain targeting in rats of Salvianolic acid B nasal delivery by the microdialysis technique
Suiling Zhang, Yajun Shi, Lizhi Tang, Jing Wang, Dongyan Guo, Mei Wang & Xiaofei Zhang
Pages: 851-859 | DOI: 10.1080/00498254.2017.1373207


Molecular Toxicology

Inhalation exposure of nano diamond induced oxidative stress in lung, heart and brain
Yahya Khosravi, Ahmad Salimi, Jalal Pourahmad, Parvaneh Naserzadeh & Enayatollah Seydi
Pages: 860-866 | DOI: 10.1080/00498254.2017.1367974


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