A Touch from Myofibroblasts Puts the Squeeze on Myonuclei

Publication date: 2 July 2018
Source:Developmental Cell, Volume 46, Issue 1
Author(s): Torrey R. Mandigo, Eric S. Folker
The even positioning of nuclei at the periphery of differentiated myofibers is among the most striking examples of cellular organization. In this issue of Developmental Cell, Roman et al. (2018) show that fibronectin deposited by the associated myofibroblasts initiates both lateral and peripheral nuclear movements by distinct downstream mechanisms.

Teaser

The even positioning of nuclei at the periphery of differentiated myofibers is among the most striking examples of cellular organization. In this issue of Developmental Cell, Roman et al. (2018) show that fibronectin deposited by the associated myofibroblasts initiates both lateral and peripheral nuclear movements by distinct downstream mechanisms.


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