Rifampin alone may be enough. Is it time to abandon the classic oral clindamycin ‐ rifampicin combination for hidradenitis suppurativa?

Abstract

In this issue, a "Critically Appraised Topic" assesses the long‐term safety of clindamycin and rifampicin in hidradenitis suppurativa (HS). ¹ It concludes that the long‐term use of these drugs is generally safe.

As described in the CAT, the treatment approach with rifampicin was adapted from a case of dissecting cellulitis successfully treated with rifampicin as a monotherapy. ¹ Based on hypothetical thinking, clindamycin was added to rifampicin to prevent the possible resistance development of Staphylococcus aureus, that was considered the pathophysiological essential bacteria of dissecting cellulitis.

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