Ετικέτες

Τρίτη 18 Δεκεμβρίου 2018

Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis

Publication date: Available online 17 December 2018

Source: Autoimmunity Reviews

Author(s): Thomas Barba, Romain Fort, Vincent Cottin, Steeve Provencher, Isabelle Durieu, Sabine Jardel, Arnaud Hot, Quitterie Reynaud, Jean-Christophe Lega

Abstract
Objective

Interstitial lung disease (ILD) is the most severe complication of idiopathic inflammatory myositis (IIM), resulting in significant increase in morbidity and mortality and for which the best treatment remains controversial. We conducted a meta-analysis to evaluate the efficacy of therapies used for the management of IIM-related ILD.

Methods

Studies were selected from MEDLINE up to July 2017. Two investigators independently extracted data on study design, patient characteristics, clinical features, treatment, follow-up and outcomes. Global survival rates and objectively confirmed lung function improvements were extracted as the main outcome for rapidly progressive IIM-related ILD (RP-ILD) and chronic forms of ILD (C-ILD), respectively, and pooled using the weighted mean proportion with fixed or random-effects models in case of significant heterogeneity (I2 > 50%).

Results

Twenty-seven studies encompassing 553 patients (male: 30.5%, age: 53.5 ± 5.5 years) were included in the meta-analysis. Globally, retrieved studies were of limited methodological quality (no controlled studies and only 2 prospective studies). Dermatomyositis (40%) and anti-tRNA synthetase syndrome (45%) were the most represented IIM subtypes. In C-ILD, functional improvement rates were 89.2% (95%CI 82.5–93.6; 7 studies, n = 124) for corticosteroids alone, 80.7% (95%CI 49.6–94; 6 studies, n = 38) for cyclosporine A, 64.1% (95%CI 46.3–78.7; 4 studies, n = 32) for azathioprine, 86.2% (95%CI 61.5–96; 2 studies, n = 23) for tacrolimus, 56.4% (95%CI 44–68.0; 8 studies, n = 71) for cyclophosphamide, and 76.6% (95%CI 50.4–96.0; 2 studies, n = 20) for rituximab. In RP-ILD, survival rates at 3 months were 51.7% (95%CI 24.2–78.1; 2 studies, n = 11) for corticosteroids alone, 69.2% (95%CI 55.0–80.5; 8 studies, n = 146) for cyclosporine A and 72.4% (95%CI 6.4–99.0, 2 studies, n = 16) for cyclophosphamide.

Conclusion

Despite aggressive immunosuppressive therapies, the short-term mortality of RP-ILD remains high. While immunosuppressive therapies are associated with significant functional improvements in most patients with C-ILD, substantial uncertainty remains about the best treatment strategy in the absence of good quality evidence.



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