Who Should Undergo Chronic Total Occlusion Percutaneous Coronary Intervention? The EXPLORation Continues ∗

Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been growing by leaps and bounds in recent years, fueled by advances in techniques, equipment, and underpinning clinical evidence (1). A major gap, however, has been the lack of randomized controlled trials comparing CTO PCI with medical therapy (2).

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