Clinical implementation of coverage probability planning for nodal boosting in locally advanced cervical cancer

Publication date: Available online 9 February 2017
Source:Radiotherapy and Oncology
Author(s): Anne Ramlov, Marianne S. Assenholt, Maria F. Jensen, Caroline Grønborg, Remi Nout, Markus Alber, Lars Fokdal, Kari Tanderup, Jacob Chr. Lindegaard
PurposeTo implement coverage probability (CovP) for dose planning of simultaneous integrated boost (SIB) of pathologic lymph nodes in locally advanced cervical cancer (LACC).Material and methodsCovP constraints for SIB of the pathological nodal target (PTV-N) with a central dose peak and a relaxed coverage at the perimeter were generated for use with the treatment planning system Eclipse: PTV-N D98 >90%, CTV-N D98 >100% and CTV-N D50 >101.5% of prescribed dose. Dose of EBRT was 45Gy/25 fx with a SIB of 55–57.5Gy depending on expected dose from brachytherapy (BT). Twenty-five previously treated patients with 47 boosted nodes were analysed. Nodes were contoured on cone beam CT (CBCT) and the accumulated dose in GTV-NCBCT and volume of body, pelvic bones and bowel receiving >50Gy (V50) were determined.ResultsNearly all nodes (89%) were visible on CBCT and showed considerable concentric regression during EBRT. Total EBRT and BT D98 was >57 GyEQD2 in 98% of the visible nodes. Compared to treatment plans aiming for full PTV-N coverage, CovP significantly reduced V50 of body, bones and bowel (p<0.001)ConclusionCovP is clinically feasible for SIB of pathological nodes and significantly decreases collateral SIB dose to nearby OAR.



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