HO-2 Pockets Myristoylated Gag

Publication date: 8 February 2017
Source:Cell Host & Microbe, Volume 21, Issue 2
Author(s): Marilyn D. Resh
Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively sequestering myristate. In this issue of Cell Host & Microbe, Zhu et al. (2017) report on a myristate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.

Teaser

Membrane binding of viral and cellular N-myristoylated proteins can be regulated by selectively sequestering myristate. In this issue of Cell Host & Microbe, Zhu et al. (2017) report on a myristate binding site within the cellular protein heme oxygenase-2 that acts as a trap to inhibit N-myristoylated protein function.


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