Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation

Publication date: 8 February 2017
Source:Cell Host & Microbe, Volume 21, Issue 2
Author(s): David Komander, Felix Randow
Three recent papers, including one by Kotewicz et al. (2016) in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole. Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.

Teaser

Three recent papers, including one by Kotewicz et al. in this issue of Cell Host & Microbe, show that Legionella deploys a novel form of ubiquitylation to generate its replicative vacuole. Without E1 and E2 enzymes, SidE effectors ubiquitylate serine residues in substrates via an ADP-ribosylated ubiquitin intermediate.


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