Pediatric Oncology Enters the Era of Precision Medicine

Publication date: Available online 1 February 2017
Source:Current Problems in Cancer
Author(s): Nita L. Seibel, Katherine Janeway, Carl E. Allen, Susan N. Chi, Y Jae Cho, Julia L. Glade Bender, AeRang Kim, Theodore W. Laetsch, Meredith S. Irwin, Naoko Takebe, James V. Tricoli, D. Williams Parsons
With the use of high-throughput molecular profiling technologies, precision medicine trials are ongoing for adults with cancer. Similarly, there is interest in how these techniques can be applied to tumors in children and adolescents to expand our understanding of the biology of pediatric cancers and evaluate the clinical implications of genomic testing for these patients. This article will review the early studies in pediatric oncology showing the feasibility of this approach, describe the future plans to evaluate the clinical implications in a multicenter clinical trial and identify the challenges of applying genomics in this patient population.



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