Pushing Yap into the Nucleus with Shear Force

Publication date: 27 March 2017
Source:Developmental Cell, Volume 40, Issue 6
Author(s): Jason Kuan Han Lai, Didier Y.R. Stainier
Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.

Teaser

Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.


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