Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection

Publication date: 15 January 2018
Source:Biosensors and Bioelectronics, Volume 99
Author(s): Phan Thi Kim Loan, Dongqin Wu, Chen Ye, Xiaoqing Li, Vu Thanh Tra, Qiuping Wei, Li Fu, Aimin Yu, Lain-Jong Li, Cheng-Te Lin
The quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1pM to 100nM for DNA target. Our findings provide an efficient method to boost the sensitivity of graphene-based biosensors for DNA recognition.

Graphical abstract

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