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Τρίτη 4 Ιουλίου 2017

Resting-state fMRI correlations: From link-wise unreliability to whole brain stability

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Publication date: 15 August 2017
Source:NeuroImage, Volume 157
Author(s): Mario Pannunzi, Rikkert Hindriks, Ruggero G. Bettinardi, Elisabeth Wenger, Nina Lisofsky, Johan Martensson, Oisin Butler, Elisa Filevich, Maxi Becker, Martyna Lochstet, Simone Kühn, Gustavo Deco
The functional architecture of spontaneous BOLD fluctuations has been characterized in detail by numerous studies, demonstrating its potential relevance as a biomarker. However, the systematic investigation of its consistency is still in its infancy. Here, we analyze within- and between-subject variability and test-retest reliability of resting-state functional connectivity (FC) in a unique data set comprising multiple fMRI scans (42) from 5 subjects, and 50 single scans from 50 subjects. We adopt a statistical framework that enables us to identify different sources of variability in FC. We show that the low reliability of single links can be significantly improved by using multiple scans per subject. Moreover, in contrast to earlier studies, we show that spatial heterogeneity in FC reliability is not significant. Finally, we demonstrate that despite the low reliability of individual links, the information carried by the whole-brain FC matrix is robust and can be used as a functional fingerprint to identify individual subjects from the population.



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