Revisiting murine models for atopic dermatitis and psoriasis with multipolar cytokine axes

Publication date: October 2017
Source:Current Opinion in Immunology, Volume 48
Author(s): Kenji Kabashima, Takashi Nomura
Atopic dermatitis (AD) and psoriasis are one of the common skin diseases. Animal models are a powerful tool to analyze these diseases, which are complicated by multiple cytokine pathways. However, many discrepancies between the human diseases and murine models have been noticed. Therefore, investigators should be aware of the differences between the murine AD models and human AD when translating murine data to human skin diseases. This review highlights the differences between the inflammatory profiles between murine models and human diseases focusing on AD and psoriasis.



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