Publication date: Available online 17 November 2017
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Author(s): Osama Abdel Hamid
BackgroundCefpodoxime is a broad spectrum third generation cephalosporin with antibacterial activity similar to parenteral cephalosporins. Active against Gram-negative and -positive bacteria, empirical treatment with cefpodoxime is recommended for a wide range of community-acquired infections. We assessed the efficacy of cefpodoxime for the treatment of upper respiratory tract infections (URTI) in Egyptian adults, and evaluated its safety in daily practice.MethodsThis prospective, observational, multicentre study recruited adult patients, presenting with acute maxillary sinusitis and tonsilopharyngitis, prescribed 200mg/day cefpodoxime for 5–10days by their physicians decision. Effectiveness, defined as the proportion of patients exhibiting a complete recovery of clinical symptoms for acute sinusitis and tonsilopharyngitis, was assessed. Safety was evaluated by measuring the prevalence and severity of adverse events (AEs).ResultsA total of 1425 adult patients were recruited from 134 centers across Egypt. Significant reductions in URTI-related signs and symptoms were observed in subjects prescribed cefpodoxime for a mean 5.87±1.73days. An 83.3% cure rate and a 16.2% improvement rate were noted for both acute maxillary sinusitis and tonsilopharyngitis patients. Superior outcomes were observed in patients with acute tonsilopharyngitis compared to the acute maxillary sinusitis cohort (86.3% and 77.4%, respectively; p<0.001). AEs were reported by 12 (0.8%) participants. All AEs were mild to moderate in intensity; none were serious and all were recovered.ConclusionsHigh cure rates for acute maxillary sinusitis and acute tonsilopharyngitis, and a favorable safety and tolerability profile were noted following treatment with cefpodoxime. Thus, cefpodoxime seems to be effective as empirical treatment in adult Egyptian patients with acute UTRIs.
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Πέμπτη 30 Νοεμβρίου 2017
Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry
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