Exploiting the human peptidome for novel antimicrobial and anticancer agents

Publication date: Available online 31 October 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Matteo Bosso, Ludger Ständker, Frank Kirchhoff, Jan Münch
Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds.

Graphical abstract

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