PD-1hiCXCR5−CD4+ TFH Cells Play Defense in Cancer and Offense in Arthritis

Publication date: Available online 27 October 2017
Source:Trends in Immunology
Author(s): Chunyan Gu-Trantien, Karen Willard-Gallo
T follicular helper (TFH) cells are characteristically defined by their CXCR5 positivity and homing to B cell follicles in secondary lymphoid organs (SLO). An expanded subpopulation of functionally comparable and phenotypically similar PD-1^hiCXCR5⁻CD4⁺ T cells were recently identified in breast cancer (BC) and rheumatoid arthritis (RA) to have beneficial or detrimental roles, respectively, but are they inflammatory tissue effector TFH cells?



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