Reading m6A in the Transcriptome: m6A-Binding Proteins

Publication date: Available online 2 November 2017
Source:Trends in Cell Biology
Author(s): Deepak P. Patil, Brian F. Pickering, Samie R. Jaffrey
N⁶-Methyladenosine (m⁶A) is the most prevalent post-transcriptional modification of eukaryotic mRNA and long noncoding RNA. m⁶A mediates its effects primarily by recruiting proteins, including the multiprotein eukaryotic initiation factor 3 complex and a set of proteins that contain the YTH domain. Here we describe the mechanisms by which YTH domain-containing proteins bind m⁶A and influence the fate of m⁶A-containing RNA in mammalian cells. We discuss the diverse, and occasionally contradictory, functions ascribed to these proteins and the emerging concepts that are influencing our understanding of these proteins and their effects on the epitranscriptome.



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