Vav1: Friend and Foe of Cancer

Publication date: Available online 30 October 2017
Source:Trends in Cell Biology
Author(s): Fukun Guo, Yi Zheng
A recent study shows that the protumorigenic guanine nucleotide exchange factor (GEF) Vav1 functions as a tumor suppressor in T cell acute lymphoblastic leukemia (T-ALL) through its ability to complex with the Cbl-b ubiquitin ligase and the intracellular domain of Notch1 (ICN1) and to promote ICN1 degradation. Vav1can act as a double-edged sword in tumorigenesis.



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