An improved synthesis of 1-methylcyclopropanol using the Kulinkovich reaction

Publication date: Available online 23 December 2017
Source:Bioorganic & Medicinal Chemistry
Author(s): Christine Delsarte, Guillaume Etuin, Laurent Petit
An improved process for the preparation of 1-methylcyclopropanol using the Kulinkovich reaction is described. The use of titanium tetramethoxide as catalyst resulted in minimal side product formation. The reaction, isolation and purification procedures were optimized so they can be easily implemented in multi-purpose equipment.

Graphical abstract

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