Metabolic Reprogramming via Targeting CD38 NADase Augments Adoptive T Cell Therapy

Publication date: 9 January 2018
Source:Cell Metabolism, Volume 27, Issue 1
Author(s): Mario R. Fernandez, John L. Cleveland
One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4⁺ T cell functions and memory can be improved by targeting a CD38-NAD⁺-Sirt1-Foxo1 metabolic circuit.

Teaser

One strategy to improve the potency of adoptive T cell therapy is to augment the function and persistence of anti-tumor T cells. In this issue of Cell Metabolism, Chatterjee et al. (2018) demonstrate that intratumoral CD4⁺ T cell functions and memory can be improved by targeting a CD38-NAD⁺-Sirt1-Foxo1 metabolic circuit.


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