SERCA2b Cycles Its Way to UCP1-Independent Thermogenesis in Beige Fat

Publication date: 9 January 2018
Source:Cell Metabolism, Volume 27, Issue 1
Author(s): Emilio P. Mottillo, Vanesa D. Ramseyer, James G. Granneman
A new study in Nature Medicine, by Ikeda et al. (2017), reports that calcium cycling in beige adipocytes elevates energy expenditure and glucose oxidation in the absence of uncoupling protein 1. Thermogenic calcium cycling in beige fat is mediated by SERCA2b and improves cold tolerance and metabolic status.

Teaser

A new study in Nature Medicine, by Ikeda et al. (2017), reports that calcium cycling in beige adipocytes elevates energy expenditure and glucose oxidation in the absence of uncoupling protein 1. Thermogenic calcium cycling in beige fat is mediated by SERCA2b and improves cold tolerance and metabolic status.


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